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After the gut-brain and gut-skin axis, it's time to explore yet another fascinating link between gut bacteria and the body: the gut-hormone connection. Gut health and hormones are connected through chemical messengers and microbial metabolites that influence cortisol, estrogen, insulin, and more.
In the following parts, we'll take a closer look at how gut health affects hormones, signs of hormonal imbalance (due to poor gut health), and what you can eat/do to support both.
How does gut health affect hormones? The gut and its microbial community influence hormones through distinct, sometimes overlapping pathways:
- The first one is a group of gut bacteria, the "estrobolome," that help process estrogen in the body. When they're balanced, the liver can efficiently clear out excess estrogen. But when they're disrupted (due to a poor diet, stress, etc.), they'll act as a trigger for hormonal disorders, as shown by a recent MDPI-published study.
- The second pathway is the gut-brain axis. This two-way neural network enables your microbiome to communicate directly with the brain. It influences how your body produces and responds to cortisol, the primary hormone responsible for your energy, alertness, and stress responses.
- Finally, gut microbes regulate blood sugar and insulin sensitivity by producing short-chain fatty acids (SCFAs), and their effect on inflammation. They also influence how your body metabolizes thyroid hormones into their active form.

Does gut health affect hormones? Yes, and here are the most common symptoms of this issue:
Note: Although these symptoms can result from gut dysbiosis (and the hormonal fluctuations that follow), they can have other causes. When they cluster with GI symptoms, it's primarily due to poor gut-hormone health.

Smooth digestion aside, a diverse microbiome produces beneficial metabolites that help stabilize hormone levels, preserve energy balance, and support mood and cognition.
These benefits of insulin, cortisol, and thyroid are definite, but gradual. With the right lifestyle and dietary pattern that consistently nourishes your gut, you'll have better metabolic health and a lower risk of developing hormone-related disorders.
Hormonal balance starts with the gut, the digestive organ that's also metabolic. Nurture your microbiome with the right foods and habits to support gut and hormonal health.
And if you're looking for a more personalized nutrition plan that supports unique gut and hormonal needs, try data-driven tools like UP-Diet.